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James-OstellNational Center for Biotechnology Information, USA
Tues., Jan. 12 - 8:45 AM
Town & Country Ballroom

Talk Topic: Biotechnology, Biomedicine, and Ag Genomics Databases at the NCBI

Talk Title: The Genome Era at NCBI – Are We There Yet?

Not so long ago publishing the genome of new organism was the domain of large teams and high profile papers. But now genomes are becoming tools of the trade. The NCBI Eukaryotic Genome Pipeline (GPIPE) has annotated more than 250 eukaryotic genomes. The bacterial version of GPIPE can assemble and annotate up to 700 genomes a day, and NCBI offers bacterial genome annotation as service to GenBank submitters routinely. We now have thousands of bacterial genomes from type strains, making it more reliable now to determine a bacterial species by comparing the genome than relying on the asserted organism name. Thousands of bacteria and virus samples are being sequenced and assembled into complete genomes as part of food pathogen or infectious disease surveillance, and 100’s of thousands of human genomes are starting to be sequenced now. What does the world look like when one sequences a genome as an assay instead of as an original discovery in its own right? NCBI is well down this road already, and this presentation will describe a bit of what we are starting to see.

Bio: Dr. Ostell is the Chief of the Information Engineering Branch (IEB) of the National Center for Biotechnology Information (NCBI). Dr. Ostell earned a Ph.D. in molecular biology from Harvard University, developed commercial software for biotechnology, then helped create NCBI in 1988. As IEB Chief, Dr. Ostell has been responsible for designing, developing, building, and deploying almost all production resources at NCBI from its beginning including PubMed, GenBank, BLAST, Entrez, RefSeq, dbSNP, PubMed Central, dbGaP, and many others. IEB serves more than 3 million users a day at peak rates of more than 7000 web hits a second. In 2007 Dr. Ostell was inducted into the United States National Academies, Institute of Medicine, and made an NIH Distinguished Investigator in 2011.